![]() ![]() They also looked at how these risks differed before and after waves of infection that were dominated by the Alpha, Delta, and Omicron variants, respectively. Next, the authors analyzed the participants’ risk for 14 psychiatric and neurological diagnoses and compared the risk for these disorders to the control cohort. The researchers first identified nearly 1.2 million patients who had become infected with SARS-CoV-2 between January 20, 2020, and April 13, 2022, and pair matched them with others who had the same vaccination status, age, demographic and risk factors, who had not had COVID-19 but had experienced other respiratory infections. The majority of data were from the United States, but the study also included data from a number of other countries. doi: 10.1016/j. used data collected as part of a 2-year retrospective cohort studies from the TriNetX electronic health records network to investigate the impact of the neurological and psychiatric impact of SARS-CoV-2 infections. Post-acute COVID-19 syndrome and its prolonged effects: An updated systematic review. Persistence of somatic symptoms after COVID-19 in the Netherlands: An observational cohort study. doi: 10.1038/s41593-z.īallering A.V., van Zon S.K.R., Olde Hartman T.C., Rosmalen J.G.M., Lifelines Corona Research I. Nalbandian A., Sehgal K., Gupta A., Madhavan M.V., McGroder C., Stevens J.S., Cook J.R., Nordvig A.S., Shalev D., Sehrawat T.S., et al. doi: 10.1016/S1473-3099(21)00703-9.Ĭarfi A., Bernabei R., Landi F., The Gemelli Against COVID-19 Post-Acute Care Study Group Persistent Symptoms in Patients after Acute COVID-19. ![]() ![]() ![]() Soriano J.B., Murthy S., Marshall J.C., Relan P., Diaz J.V., WHO Clinical Case Definition Working Group on Post-COVID-19 Condition A clinical case definition of post-COVID-19 condition by a Delphi consensus. Omicron variant chronic fatigue insomnia long COVID myalgic encephalomyelitis post COVID-19 condition. The prevalence of sleep disturbance has been increasing in long COVID patients infected in the Omicron phase with a certain clinical and endocrine trend. Endocrine examinations revealed that long COVID patients with sleep disturbance had significantly higher levels of plasma adrenocorticotropin and lower levels of serum growth hormone, suggesting the presence of hypothalamic-pituitary stress. Among the types of sleep disturbance, the percentage of patients who complained of loss of sleep induction (75%) was much higher than the percentage of patients with early-awakening sleep disturbance (6.7%), and many of the patients with mid-awakening types of insomnia had brain fog symptoms. Of note, the percentages of patients with sleep disturbance who also complained of general fatigue, headache, concentration loss, anxiety, low-grade fever, and brain fog symptoms were higher than the percentages of patients without sleep disturbance who had the same complaints. In addition, the prevalence rate of sleep disturbance in patients when infected in the Omicron phase (24.8%) was two-times higher than that in patients infected in the Delta phase (12.8%). Although there were no significant differences in clinical backgrounds and severities of COVID-19 between the two groups by the multivariate analysis, the percentage of long COVID patients with sleep disturbance was significantly increased among patients infected in the Omicron-dominant phase. Out of 363 patients with long COVID, after excluding 6 patients, 60 patients (16.5%) (55% males, median age of 38 years) complaining of sleep disturbance were compared with 303 patients (83.5%) (43% males, median age of 40 years) without sleep-related symptoms. The long COVID patients were divided into two groups based on the presence or absence of sleep disturbance, and the clinical and laboratory characteristics of the patients were analyzed. This study was a single-center retrospective observational study for patients who visited the COVID-19 aftercare outpatient clinic (CAC) established in Okayama University Hospital in Japan during the period from 15 February 2021 to 29 July 2022. The objective of this study was to determine the clinical and endocrinological features of sleep disturbance in patients with long COVID. ![]()
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